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Could a Coral Reef Cyanobacterium Aid Treating Serious Bone Fractures and Disease in Humans?

By Shane Graber - Posted Mar 07, 2011 08:50 PM
Published this week in the ACS Medicinal Chemistry Letters, researchers have discovered that a coral reef cyanobacterium that produces the compound largazole could help treat serious bone problems, disease and tumors.
Could a Coral Reef Cyanobacterium Aid Treating Serious Bone Fractures and Disease in Humans?

Photo by Aldo Croquer. AAOLM, February 2008 Issue.

As if we didn't already know that our imperilled reefs are important to save, a tiny cyanobacterium that's found inhabiting reefs has shown its importance in fighting disease.

This particular cyanobacterium produces a compound called Largazole, which is named for the place that it was first discovered: Key Largo, FL.  In previous studies published in 2008, the compound was shown to have anti-tumor properties and was observed to be effective in fighting colon cancer.

In further work with the molecule published recently in the ACS Medicinal Chemistry Letters, researchers have now shown that this compound also aids in bone regeneration from serious bone fractures and osteoperosis through a process called osteogenesis.  It performs two functions in this process:

  1. Stimulates bone growth and regeneration
  2. Blocks the breakdown and reabsorption of bone by the body

It was also shown that mixed with calcium phosphate, collagen, and other biomaterials that it can be used for bone grafting.

(via College of Pharmacy, University of Florida and American Chemical Society)

Author: Shane Graber
Location: Indiana

Shane has kept saltwater tanks for the last 12 years, is a research scientist, lives in northern Indiana, and is a proud Advanced Aquarist staffer.

Website: http://www.advancedaquarist.com/.

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